There is no way of predicting your response to travel to altitude (either trekking or flights to cities eg. Cusco). It is remarkable how many travellers believe that a 'headache' at altitude is normal, it is not ! If you are carrying altitude medication, always carry a package insert in the actual medication container to refer to so you know when, how to use and how to titrate.   

Preventative medication include gingko, acetazolomide and dexamethasone. The treatment of altitude sickness is descent, however some of drugs can be used as treament .

Denial is also common - be willing to admit that you have altitude sickness, as that is the first step to stay out of trouble.

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